EVENT DETAILS

 Siliconization is an important step in pre-filled glass syringe production. The correct deposition profile is vital for ensuring the proper operation of autoinjector devices.
Silicone oil is suspected of triggering the aggregation of protein and generation of sub-visibile particles if present in excessive quantity.
In the last year great efforts have been dedicated to techniques for controlling the deposition of silicon oil, droplet size and layer thickness designing special nozzles and characterizing the aerosol spray by digital imaging.
The role of glass surface conditioning has been studied through the silicon oil contact angle measurement in different operating conditions and from several glass suppliers.
A step forward in the siliconization process will be to control 100% the deposited layer in production. The study investigated the different techniques available for measuring the silicon layer identifying the most suited for in-line integration. The development of an inspection unit capable of 12.000 syringes/hour is in progress .